Telemedicine has been on the rise for decades—including home-based, technology-driven interaction with healthcare providers. It is used today in setting up diagnosis, medical counselling as well as continuous follow ups of patients with chronical diseases. This literature data review intends to present new findings related to the trend of telemedicine, specifically related to the use and creation of telemedicine in Serbia. The primary benefit of telemedicine is possibility of providing medical consultations to patients who live far away or have other difficulties in reaching a medical facility for regular evaluations, suchas patients suffering from many neurological, oncological, or autoimmune diseases. With telemedicine, assessments, intervention, and treatment can occur promptly. In addition, with more and more evaluations occurring (studies have shown this to be of benefit to patients), telemedicine decreases the costs and administrative burden on hospitals—as requirements for monthly in-facility evaluations cited decrease—if the process can be successfully achieved. Medical systems and facilities can reduce costs while experiencing better results in treatment efficiency, efficacy, and satisfaction with provided services.